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Image Search Results
Journal: American Journal of Cancer Research
Article Title: The small-molecule drug homoharringtonine targets HSF1 to suppress pancreatic cancer progression
doi: 10.62347/XFJH3424
Figure Lengend Snippet: HHT targets HSF1 to inhibit pancreatic cancer cells proliferation. A. HSF1 expression assessed by western blot across 6 PC cell lines. B. HHT selectively inhibited PC cells growth with high HSF1 expression, as determined by MTS assay (n=3). C, D. HHT was less effective in the HSF1 knockdown PC cells. E. Schematic of molecular docking showing potential binding mode of HHT to HSF1 DBD. F. Cellular thermal shift assay (CETSA) of HSF1 with HHT treatment in MIAPACa-2. G. HHT bound to HSF1 and the binding affinity was quantitatively assessed by MTS experiments (n=3).
Article Snippet: Following a 72 h treatment with HHT, KRIBB11 or DTHIB exposure, 20 μL
Techniques: Expressing, Western Blot, MTS Assay, Knockdown, Binding Assay, Thermal Shift Assay